ANTI-HIV-I ACTIVITY OF LINKED LEXITROPSINS

被引：51

作者：

WANG, WY ^{[1
]}

LOWN, JW ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 15期

关键词：

D O I：

10.1021/jm00093a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five groups of lexitropsin oligopeptides have been synthesized that are structurally related to the natural antiviral agents netropsin and distamycin and bearing two such moieties joined by flexible or rigid linkers. Inhibitory activity of these types of agents against murine leukemia retrovirus (MuLV) led to an evaluation of their inhibition of HIV-I in cell culture. The antiretroviral activity of the five different classes of lexitropsins is discussed in terms of their structural differences.

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页码：2890 / 2897

页数：8

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