AUTOPSY REPORT OF ACUTE NECROTIZING OPTICOMYELOPATHY ASSOCIATED WITH THYROID-CANCER

被引：20

作者：

KURODA, Y ^{[1
]}

MIYAHARA, M ^{[1
]}

SAKEMI, T ^{[1
]}

MATSUI, M ^{[1
]}

RYU, T ^{[1
]}

YAMAGUCHI, M ^{[1
]}

SASADOMI, E ^{[1
]}

SUGIHARA, H ^{[1
]}

机构：

[1] SAGA MED SCH,DEPT PATHOL,SAGA 849,JAPAN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 120卷 / 01期

关键词：

ACUTE NECROTIZING MYELOPATHY; PARANEOPLASTIC NEUROLOGICAL SYNDROME; THYROID CANCER; MYELIN BASIC PROTEIN; DEMYELINATION; AUTOIMMUNE DISEASE;

D O I：

10.1016/0022-510X(93)90020-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report an autopsied case of paraneoplastic necrotizing myelopathy. The patient had bilateral blindness, quardriplegia, and dyspnea of acute onset and died without remission 7 weeks later. The severe tissue necrosis and demyelination were found in the optic chiasm and from the medulla oblongata throughout the whole length of spinal cord. A papillary carcinoma was found in the thyroid gland at autopsy. In the present case IgG, myelin basic protein and activated helper T cells were increased in the CSF at onset, suggesting a mechanism of autoimmune demyelination for the condition.

引用

页码：29 / 32

页数：4

共 17 条

[1] PARA-NEOPLASTIC CEREBELLAR DEGENERATION - CLINICAL-IMMUNOLOGICAL CORRELATIONS [J].