SYNERGISTIC EFFECT OF CHOLINE AND CARNITINE ON ACETYLCHOLINE SYNTHESIS IN NEUROBLASTOMA NB-2A CELLS

被引：15

作者：

WAWRZENCZYK, A ^{[1
]}

NALECZ, KA ^{[1
]}

NALECZ, MJ ^{[1
]}

机构：

[1] POLISH ACAD SCI,M NENCKI INST EXPTL BIOL,PL-02093 WARSAW,POLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1935

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An influence of carnitine on acetylcholine synthesis from radiolabeled glucose was monitored in neuroblastoma NB-2a cells. Upon addition of carnitine the distribution of its derivatives was found significantly different than the values published for brain, the level of long-chain acyl derivatives being much higher and reaching 60%. Carnitine itself did not change acetylcholine level. Together with choline (20 mu M), carnitine was observed to stimulate (by 36%) acetylcholine synthesis in a synergistic way, which indicated that both substrates could be limiting factors of this process in NB-2a cell line of neuroblastoma. (C) 1994 Academic Press, Inc.

引用

页码：354 / 359

页数：6

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