HOW MUSCLE MAY CONTRACT

被引：14

作者：

ELLIOTT, GF ^{[1
]}

WORTHINGTON, CR ^{[1
]}

机构：

[1] CARNEGIE MELLON UNIV,PITTSBURGH,PA 15213

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1994年 / 1200卷 / 02期

关键词：

MUSCLE CONTRACTION; MOLECULAR MODEL; SNAP-BACK MODEL;

D O I：

10.1016/0304-4165(94)90124-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new molecular model is proposed for muscle contraction, that involves the electrical charging of the long (C-terminal) alpha-helical part of the head of the myosin molecule (S1) while the head is attached to actin; as it charges the alpha-helical part moves in the radial electric field between the filaments. The alpha-helical part snaps back when the myosin molecule is discharged electrically, at the moment that ATP binds to the active enzymatic site. This snap-back model explains several puzzling phenomena in contractility, as well as providing a physical explanation for the origin of an impulsive force that drives muscle contraction.

引用

收藏

页码：109 / 116

页数：8

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