HYPOTENSIVE AGENTS . (+)- AND (-)-2-METHOXY-2-(3-METHOXYPHENYL)-ETHYLAMINE AND RELATED COMPOUNDS

2-Methoxy-2-(3-methoxyphenyl)ethylamine (1) has been shown to produce a hypotensive effect in chloralosed cats at doses very much smaller than those which cause adverse effects. It appears to lower the blood pressure by inhibiting the pressor responses resulting from central nervous system reflex control and not by ganglionic blockade or peripheral adrenergic blockade. The hypotensive effect is produced by the (—) isomer of 1 and not by the (+) isomer. Nineteen analogs of 1 are described. © 1969, American Chemical Society. All rights reserved.