CONTINUOUS COENZYME-DEPENDENT STEREOSELECTIVE SYNTHESIS OF SULCATOL BY ALCOHOL-DEHYDROGENASE

被引：28

作者：

ROTHIG, TR

KULBE, KD

BUCKMANN, F

CARREA, G

机构：

[1] Fraunhofer-Institut für Grenzflächen-und Bioverfahrenstechnik, Stuttgart 80, D-7000

来源：

BIOTECHNOLOGY LETTERS | 1990年 / 12卷 / 05期

关键词：

D O I：

10.1007/BF01024430

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

6-methyl-5-hepten-2-one was reduced to sulcatol ((+)-6-methyl-5-hepten-2-ol) by using alcohol dehydrogenase from Thermoanaerobium brockii in a continuous process. The cofactor NADP(H) was retained by a charged UF-membrane and regenerated by oxidation of isopropanol to acetone. Use of native NADP in a charged UF-membrane reactor proved to be superior to use of PEG coupled NADP in a uncharged UF-membrane reactor. © 1990 Kluwer Academic Publishers.

引用

页码：353 / 356

页数：4

共 8 条

[1] USE OF BIOLOGICAL-SYSTEMS FOR THE PREPARATION OF CHIRAL MOLECULES .3. AN APPLICATION IN PHEROMONE SYNTHESIS - PREPARATION OF SULCATOL ENANTIOMERS [J].