SYNTHESIS OF VITAMIN-D5 - ITS BIOLOGICAL-ACTIVITY RELATIVE TO VITAMIN-D3 AND VITAMIN-D2

被引：31

作者：

NAPOLI, JL ^{[1
]}

FIVIZZANI, MA ^{[1
]}

SCHNOES, HK ^{[1
]}

DELUCA, HF ^{[1
]}

机构：

[1] UNIV WISCONSIN,COLL AGR & LIFE SCI,DEPT BIOCHEM,MADISON,WI 53706

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 197卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0003-9861(79)90226-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical synthesis, spectral characterization, and biological activity of vitamin D5 in vitamin D-deficient rats is reported. Vitamin D5 is about 180-fold less active than vitamin D3 in calcification of rachitic cartilage and about 100- to 200-fold less active in induction of bone-calcium mobilization. In stimulation of intestinal-calcium transport, vitamin D5 is about 80-fold less active than vitamin D3. Vitamins D2 and D3 appear to be equiactive in all three responses when low doses are administered. © 1979.

引用

页码：119 / 125

页数：7

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