NON-CS PREERYTHROCYTIC PROTECTIVE ANTIGENS

被引：44

作者：

HOLLINGDALE, MR

AIKAWA, M

ATKINSON, CT

BALLOU, WR

CHEN, GX

LI, J

MEIS, JFGM

SINA, B

WRIGHT, C

ZHU, JD

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT MED PARASITOL,NIJMEGEN,NETHERLANDS

[2] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

[3] UNIVAX BIOL INC,ROCKVILLE,MD

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

关键词：

Exoerythrocytic; Malaria; Non-CS; Protection; Sporozoite; Vaccine;

D O I：

10.1016/0165-2478(90)90094-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro. © 1990.

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收藏

页码：71 / 76

页数：6

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