DETERMINATION OF TEMAFLOXACIN, SARAFLOXACIN, AND DIFLOXACIN IN BULK DRUG AND DOSAGE FORMS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：15

作者：

BAUER, JF ^{[1
]}

ELROD, L ^{[1
]}

FORNNARINO, JR ^{[1
]}

HEATHCOTE, DE ^{[1
]}

KROGH, SK ^{[1
]}

LINTON, CL ^{[1
]}

NORRIS, BJ ^{[1
]}

QUICK, JE ^{[1
]}

机构：

[1] ABBOTT LABS,ANALYT RES DEPT,N CHICAGO,IL 60064

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 11期

关键词：

ciprofloxacin; difloxacin; high-performance liquid chromatography; norfloxacin; sarafloxacin; temafloxacin;

D O I：

10.1023/A:1015992511885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The fluoroquinolones, temafloxacin, sarafloxacin, and difloxacin, are determined in the bulk drug substances and in a variety of dosage forms using high-performance liquid chromatography (HPLC). The HPLC system used is also applicable for ciprofloxacin and norfloxacin. The procedure uses UV detection at 280 nm, which provides a linear response of the subject compounds to at least 20 µg/ml. Assay precision (RSD) values were ±1.2% or better for the bulk drugs and ranged from ±0.42 to ±2.3% for suspension, capsule, and tablet formulations. Drug recoveries were quantitative from the dosage forms tested. Sensitivity of the subject compounds is approximately 50 ng/ml (2.5 ng on column). © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1177 / 1180

页数：4

共 13 条

[1] COMPARISON OF HIGH-PRESSURE LIQUID-CHROMATOGRAPHY AND MICROBIOLOGICAL ASSAY FOR THE DETERMINATION OF BILIARY ELIMINATION OF CIPROFLOXACIN IN HUMANS [J].