THE CELL-ADHESION REGULATOR (CAR) GENE, TAQI AND INSERTION DELETION POLYMORPHISMS, AND REGIONAL ASSIGNMENT TO THE PERITELOMERIC REGION OF 16Q BY LINKAGE ANALYSIS

被引：25

作者：

KOYAMA, K ^{[1
]}

EMI, M ^{[1
]}

NAKAMURA, Y ^{[1
]}

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,1-37-1 KAMI IKEBUKURO,TOSHIMA KU,TOKYO 170,JAPAN

来源：

GENOMICS | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1173

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have identified two types of polymorphism at the CAR (cell adhesion regulator) locus. One is a conventional TaqI polymorphism and the other is an insertion/deletion polymorphism in the coding region. One has the nucleotide sequence AGTGAGGCA (Ser-Gln-Ala) at nt 271-279, whereas the variant has ACAC ̄ -AGTGAGGC CC ̄A(Thr-Gln-Ser-Gly-Pro). Although it is not clear whether this variation of amino acids affects the biological function of the gene product, this variant was detected in nine chromosomes among 30 unrelated Japanese individuals. Genetic linkage analysis based on the genotypes of TaqI polymorphism in CEPH families revealed close linkage of CAR to D16S7 and D16S154, which are located in the peritelomeric region of the long arm of chromosome 16. © 1993 Academic Press. All rights reserved.

引用

页码：264 / 265

页数：2

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