MESODERMAL PATTERNING BY A GRADIENT OF THE VERTEBRATE HOMEOBOX GENE GOOSECOID

被引：148

作者：

NIEHRS, C

STEINBEISSER, H

DEROBERTIS, EM

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT CHEM,LOS ANGELES,CA 90024

来源：

SCIENCE | 1994年 / 263卷 / 5148期

关键词：

D O I：

10.1126/science.7905664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amphibian mesoderm arises from the marginal zone of the early gastrula and generates various tissues such as notochord, muscle, kidney, and blood. Small changes (twofold) in the amount of microinjected messenger RNA encoding the goosecoid (gsc) homeodomain protein resulted in marked changes in the differentiation of mesoderm in Xenopus laevis. At least three thresholds were observed, which were sufficient to specify four mesodermal cell states. Endogenous gsc messenger RNA was expressed in the marginal zone in a graded fashion that is congruent with a role for this gene in dorso-ventral patterning of mesoderm at the early gastrula stage.

引用

页码：817 / 820

页数：4

共 27 条

[1] EXPRESSION OF A DOMINANT NEGATIVE MUTANT OF THE FGF RECEPTOR DISRUPTS MESODERM FORMATION IN XENOPUS EMBRYOS [J].