MAXIMUM-LIKELIHOOD CRITERION AND SINGLE-MOLECULE DETECTION

被引：14

作者：

ENDERLEIN, J

机构：

[1] Gesellschaft zur Förderung der naturwissen-schaftlichen Forschung, Eingetragener Verein, Arbeitsgruppe Laser-diagnostik, Berlin, O-1199

来源：

APPLIED OPTICS | 1995年 / 34卷 / 03期

关键词：

FLUORESCENCE DETECTION; SINGLE-MOLECULE DETECTION; MAXIMUM LIKELIHOOD; TIME-CORRELATED SINGLE-PHOTON COUNTING;

D O I：

10.1364/AO.34.000514

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The maximum-likelihood criterion is shown to be a powerful method for analyzing fluorescence-detection data with small signal-to-noise ratios. A probability study of the maximum-likelihood criterion for a supposed single-molecule detection experiment is presented that takes into account the photokinetics of the molecule to be detected, its diffusion, and the laser-beam geometry. Furthermore, the efficiency of time-integrated and time-correlated single-photon counting methods are studied and compared.

引用

页码：514 / 526

页数：13

共 21 条

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