A study of the hydrophilic cellulose matrix: Effect of indomethacin and a water-soluble additive on swelling properties

被引：21

作者：

Panomsuk, SP ^{[1
]}

Hatanaka, T ^{[1
]}

Aiba, T ^{[1
]}

Katayama, K ^{[1
]}

Koizumi, T ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,TOYAMA,JAPAN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 126卷 / 1-2期

关键词：

hydrophilic cellulose matrix; indomethacin; swelling properties; mathematical model; maximum swelling index; apparent diffusion coefficient;

D O I：

10.1016/0378-5173(95)04113-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A swelling measurement device was designed to observe the axial swelling direction of a matrix containing various types of hydrophilic cellulose derivatives (methylcellulose, hydroxypropylmethylcellulose and hydroxypropylcellulose). The effect of indomethacin and lactose on the swelling properties was also studied. The maximum swelling index and the apparent diffusion coefficient of water in the matrix, calculated from the swelling data, were used to describe the swelling properties of the matrix, reflecting the matrix integrity. The results showed that hydroxypropylcellulose produced a matrix with a high integrity. Indomethacin and lactose changed the swelling properties of the hydrophilic cellulose matrices in this study.

引用

页码：147 / 153

页数：7

共 24 条

[1]

ALDERMAN D A, 1984, International Journal of Pharmaceutical Technology and Product Manufacture, V5, P1

[2] A NOVEL NUCLEAR-MAGNETIC-RESONANCE (NMR) IMAGING METHOD FOR MEASURING THE WATER FRONT PENETRATION RATE IN HYDROPHILIC POLYMER MATRIX CAPSULE PLUGS AND ITS ROLE IN DRUG-RELEASE [J].

ASHRAF, M ;

IUORNO, VL ;

COFFINBEACH, D ;

EVANS, CA ;

AUGSBURGER, LL .

PHARMACEUTICAL RESEARCH, 1994, 11 (05) :733-737

[3] ZERO-ORDER RELEASE HYDROPHILIC MATRIX TABLETS OF BETA-ADRENERGIC BLOCKERS [J].

BAVEJA, SK ;

RAO, KVR ;

DEVI, KP .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 39 (1-2) :39-45

[4] ROUTINE FITTING OF KINETIC DATA TO MODELS - A MATHEMATICAL FORMALISM FOR DIGITAL COMPUTERS [J].

BERMAN, M ;

SHAHN, E ;

WEISS, MF .

BIOPHYSICAL JOURNAL, 1962, 2 (03) :275-&

[5] NMR MICROSCOPY OF HYDRATING HYDROPHILIC MATRIX PHARMACEUTICAL TABLETS [J].

BOWTELL, R ;

SHARP, JC ;

PETERS, A ;

MANSFIELD, P ;

RAJABISIAHBOOMI, AR ;

DAVIES, MC ;

MELIA, CD .

MAGNETIC RESONANCE IMAGING, 1994, 12 (02) :361-364

[6]

BROSIO E, 1994, CELL MOL BIOL, V40, P569

[7] SWELLING CHARACTERISTICS OF HYDROPHILIC MATRICES FOR CONTROLLED RELEASE NEW DIMENSIONLESS NUMBER TO DESCRIBE THE SWELLING AND RELEASE BEHAVIOR [J].

COLOMBO, P ;

CATELLANI, PL ;

PEPPAS, NA ;

MAGGI, L ;

CONTE, U .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 88 (1-3) :99-109

[8] PORE CHARACTERIZATION IN CELLULOSE BEADS FROM DIFFUSION STUDIES USING THE SPIN-ECHO NMR TECHNIQUE [J].

EK, R ;

HENRIKSSON, U ;

NYSTROM, C ;

ODBERG, L .

POWDER TECHNOLOGY, 1994, 81 (03) :279-286

[9] TRANSPORT-PROPERTIES OF POLYMER-SOLUTIONS - A COMPARATIVE APPROACH [J].

FOSTER, KR ;

CHEEVER, E ;

LEONARD, JB ;

BLUM, FD .

BIOPHYSICAL JOURNAL, 1984, 45 (05) :975-984

[10] INFLUENCE OF DEGREE OF CROSS-LINKING ON 5-FLUOROURACIL RELEASE FROM POLY(2-HYDROXYETHYL METHACRYLATE) HYDROGELS [J].

GARCIA, O ;

TRIGO, RM ;

BLANCO, MD ;

TEIJON, JM .

BIOMATERIALS, 1994, 15 (09) :689-694

← 1 2 3 →