FOLDING AND ASSOCIATION OF OLIGOMERIC ENZYMES

被引：36

作者：

JAENICKE, R

机构：

[1] Institut für Biophysik und Physikalische Biochemie der Universität, Regensburg

来源：

NATURWISSENSCHAFTEN | 1978年 / 65卷 / 11期

关键词：

D O I：

10.1007/BF00364906

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The spontaneous structure formation of oligomeric enzymes consists of the consecutive 'folding' and association of the constituent polypeptide chains. Whether catalytic function is an intrinsic property of the folded monomers may be determined using kinetic reconstitution experiments. It is shown that full activity requires association; the correct assembly of subunits depends on their proper folding. The native structure is determined as the kinetically accessible state of lowest free energy. © 1978 Springer-Verlag.

引用

页码：569 / 577

页数：9

共 42 条

[1]

Anfinsen C B, 1975, Adv Protein Chem, V29, P205, DOI 10.1016/S0065-3233(08)60413-1

[2] FORMATION AND STABILIZATION OF PROTEIN STRUCTURE [J].