SYNTHESIS AND PHARMACOLOGICAL SCREENING OF A NEW SERIES OF 3-(4-ANTI-PYRYL)-2-ARYLTHIAZOLIDIN-4-ONES

被引:28
作者
ALKHAMEES, HA [1 ]
BAYOMI, SM [1 ]
KANDIL, HA [1 ]
ELTAHIR, KEH [1 ]
机构
[1] KING SAUD UNIV,COLL PHARM,DEPT PHARMACOL,RIYADH 11451,SAUDI ARABIA
关键词
3-(4-antipyryl)-2-arylthiazolidin-4-one; antinociceptive activity; antipyrine; spasmolytic activity;
D O I
10.1016/0223-5234(90)90016-V
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of 3-(4-antipyryl)-2-arylthiazolidin-4-one derivatives were synthesized and pharmacologically evaluated for antinociceptive, spasmolytic and cardiovascular activities. The presence of a methoxy-naphthyl or a substituted phenyl group in 2-position of the 4-thiazolidinone ring increased the antinociceptive and spasmolytic activities by 3-12-fold compared with antipyrine. The most potent were the o-methoxy naphthalene and the m-chlorobenzene derivatives. Furthermore, the compounds showed no local anaesthetic activity, but they induced slight decreases in the rabbit arterial blood pressure. © 1990.
引用
收藏
页码:103 / 106
页数:4
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