TUNICAMYCIN-MEDIATED DEPLETION OF INSULIN RECEPTORS IN 3T3-L1 ADIPOCYTES

被引：109

作者：

ROSEN, OM

CHIA, GH

FUNG, C

RUBIN, CS

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1979年 / 99卷 / 01期

关键词：

D O I：

10.1002/jcp.1040990106

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tunicamycin, an antibiotic that inhibits protein glycosylation, elicited a rapid depletion of insulin binding activity at the surface of 3T3‐L1 adipocytes. Disappearance of insulin receptors occurred more rapidly in the presence of tunicamycin than when protein synthesis was inhibited by cycloheximide and was accompanied by a diminution in sensitivity of the adipocytes to the acute effects of insulin and anit‐insulin receptor antibody on hexose uptake and metabolism. Copyright © 1979 Wiley‐Liss, Inc.

引用

页码：37 / 42

页数：6

共 34 条

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