N,N'-DISUBSTITUTED GUANIDINE HIGH-POTENCY SWEETENERS

被引：30

作者：

MULLER, GW

WALTERS, DE

DUBOIS, GE

机构：

[1] Research & Development, NutraSweet Company, Illinois 60056, 601 E. Kensington Road, Mt. Prospect

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 04期

关键词：

D O I：

10.1021/jm00082a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role and function of the aryl group in the highly potent trisubstituted guanidine sweeteners 7a-d was investigated. Four disubstituted guanidines, lacking the aryl group, were prepared. These guanidines contain a hydrophobic substituent on one nitrogen and a carboxymethyl group substituted on one of the other nitrogens. They were found to be tasteless or to have a significantly lower sweetness potency than the corresponding trisubstituted compounds. Possible rationales for the effects of structure on the sweet taste activity are discussed.

引用

页码：740 / 743

页数：4

共 21 条

[1]

CULBERSOJ JC, 1991, SWEETNERS DISCOVERY, P214

[2] MOLECULAR MECHANICS FORCE-FIELD PARAMETERIZATION PROCEDURES [J].