AN EFFICIENT SYNTHESIS OF (-)-BULGECININE

被引：56

作者：

HIRAI, Y ^{[1
]}

TERADA, T ^{[1
]}

AMEMIYA, Y ^{[1
]}

MOMOSE, T ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,SUGITANI 2630,TOYAMA,TOYAMA 93001,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(00)74771-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoselective synthesis of (-)-bulgecinine (1) via the pyrrolido[1,2-c]oxazolidin-3-one system (2) has been achieved by starting with the asymmetric epoxidation of the twin allyl alcohol system (6). The transformation of note includes the palladium-catalyzed N-->pi cyclization leading exclusively to a trans-2,5-disubstituted pyrrolidine.

引用

页码：7893 / 7894

页数：2

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