TIMING OF NEUROENDOCRINE RESPONSES AND EFFECT OF M-CPP AND FENFLURAMINE PLASMA-LEVELS IN OCD

被引：24

作者：

HOLLANDER, E ^{[1
]}

COHEN, LJ ^{[1
]}

DECARIA, C ^{[1
]}

SAOUD, JB ^{[1
]}

STEIN, DJ ^{[1
]}

COOPER, TB ^{[1
]}

ISLAM, NN ^{[1
]}

LIEBOWITZ, MR ^{[1
]}

KLEIN, DF ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 34卷 / 06期

关键词：

M-CPP; FENFLURAMINE; PROLACTIN; CORTISOL; OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN;

D O I：

10.1016/0006-3223(93)90186-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role in cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

引用

页码：407 / 413

页数：7

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