IMMUNOHISTOCHEMICAL LOCALIZATION OF PROTEIN PHOSPHATASE ISOFORMS IN THE RAT CEREBELLUM

被引：31

作者：

HASHIKAWA, T

NAKAZAWA, K

MIKAWA, S

SHIMA, H

NAGAO, M

机构：

[1] RIKEN,INST PHYS & CHEM RES,FRONTIER RES PROGRAM,SYNAPT FUNCT LAB,WAKO,SAITAMA 35101,JAPAN

[2] NATL CANC CTR,RES INST,DIV CARCINOGENESIS,TOKYO 104,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1995年 / 22卷 / 01期

关键词：

PROTEIN PHOSPHATASE; CEREBELLUM; PURKINJE CELL; IMMUNOHISTOCHEMISTRY; RAT;

D O I：

10.1016/0168-0102(95)00886-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Protein phosphatase isoforms, PP1 gamma 1, PP1 delta, PP1 alpha and PP2A (alpha and/or beta), were immunohistochemically localized in the rat cerebellum. Purkinje cell perikarya, dendrites and spines were very PP1 gamma 1 immunoreactive. PP1 delta and PP1 alpha were perinuclear in all neurons, PP1 alpha also revealed a new cell type and PP2A was homogeneous in Purkinje cell soma and large dendrites. PP1 gamma 1 seems to be dominant for dephosphorylation at the dendritic synapses of Purkinje cells.

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页码：133 / 136

页数：4

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