ENHANCEMENT OF CORONARY REACTIVE HYPEREMIA IN UNANAESTHETIZED PIGS BY AN ADENOSINE-POTENTIATOR (LIDOFLAZINE)

The potentiation of coronary reactive hyperemia by oral doses of Lidoflazine after different periods of coronary artery occlusion in non-anaesthetized miniature pigs is described. Doses varying from 2.5 to 80 mg/kg of Lidoflazine were investigated and occlusion periods from 10 to 80 sec were used. Coronary blood flow was measured by an electromagnetic flowmeter and the occlusions were performed with a pneumatic occlusive device. The enhancement of the reactive hyperemic response is believed to result from potentiation of a transmitter substance, probably adenosine, by Lidoflazine. © 1969 Springer-Verlag.