PERCUTANEOUS-ABSORPTION ENHANCEMENT OF AN IONIC MOLECULE BY ETHANOL WATER-SYSTEMS IN HUMAN SKIN

被引:134
作者
KURIHARABERGSTROM, T [1 ]
KNUTSON, K [1 ]
DENOBLE, LJ [1 ]
GOATES, CY [1 ]
机构
[1] UNIV UTAH,CTR CONTROLLED CHEM DELIVERY,DEPT PHARMACEUT,SALT LAKE CITY,UT 84108
关键词
penetration enhancement; percutaneous absorption; stratum corneum; transdermal enhancement; transdermal permeation;
D O I
10.1023/A:1015879925147
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ethanol–water systems enhance permeation of ionic solutes through human stratum corneum. Optimum enhancement of salicylate ion permeation has been observed with ethanol volume fractions near 0.63. The mechanism of action of ethanol–water systems enhancing skin permeation was investigated by in vitro skin permeation studies combined with Fourier transform infrared spectroscopy experiments. The increased skin permeation of the ionic permeant by the ethanol–water systems may be associated with alterations involving the polar pathway. Polar pathway alterations may occur in either or both the lipid polar head and proteinaceous regions of the stratum corneum. Ion-pair formation may also contribute to increased permeation. However, the decreased permeation of salicylate ion observed at higher volume fractions of ethanol may be attributed to decreased uptake of permeant into the stratum corneum. © 1990, Plenum Publishing Corporation. All rights reserved.
引用
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页码:762 / 766
页数:5
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