LEUKOTRIENE-C - SLOW-REACTING SUBSTANCE FROM MURINE MASTOCYTOMA-CELLS

被引：1153

作者：

MURPHY, RC ^{[1
]}

HAMMARSTROM, S ^{[1
]}

SAMUELSSON, B ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT CHEM, S-10401 STOCKHOLM 60, SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 09期

关键词：

D O I：

10.1073/pnas.76.9.4275

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPL 55712. On the basis of isotope incorporation experiments, spectroscopy and chemical degradations, the SRS was identified as a cysteine-containing derivative of 5-hydroxy-7,9,11,14-icosatetraenoic acid. This amino acid was attached in thioether linkage at C-6. The SRS is structurally related to previously identified epoxy and dihydroxy metabolites of arachidonic acid in leukocytes. A common feature is the presence of a conjugated triene and the name leukotriene was introduced to designate these compounds. Leukotriene A (5,6-epoxy-7,9,11,14-icosatetraenoic acid) is an intermediate in the formation of leukotriene B (5,12-dihydroxy-6,8,10,14-icosatetraenoic acid) and may be a precursor of leukotriene C, which is the SRS identified here.

引用

页码：4275 / 4279

页数：5

共 30 条

[1]

AUSTEN K F, 1978, Journal of Immunology, V121, P793

[2]

BACH MK, 1978, J IMMUNOL, V120, P998

[3]

BACH MK, 1979, J IMMUNOL, V122, P160

[4] STRUCTURE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS - EVIDENCE OF BIOSYNTHESIS FROM ARACHIDONIC-ACID [J].

BACH, MK ;

BRASHLER, JR ;

GORMAN, RR .

PROSTAGLANDINS, 1977, 14 (01) :21-38

[5] STIMULATED PRODUCTION OF SLOW REACTING SUBSTANCES BY MERCAPTANS FROM IONOPHORE A 23187-INDUCED MONONUCLEAR-CELLS - MERCAPTAN STRUCTURE-ACTIVITY STUDIES [J].

BACH, MK ;

BRASHLER, JR .

LIFE SCIENCES, 1978, 23 (21) :2119-2126

[6] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .5. UNSTABLE INTERMEDIATE IN FORMATION OF DIHYDROXY ACIDS [J].

BORGEAT, P ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) :3213-3217

[7] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .3. EFFECTS OF IONOPHORE-A23187 [J].

BORGEAT, P ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (05) :2148-2152

[8]

BORGEAT P, 1979, J BIOL CHEM, V254, P2643

[9]

BORGEAT P, 1979, J BIOL CHEM, V254

[10] EFFECTS OF MODULATORS OF ARACHIDONIC-ACID METABOLISM ON THE SYNTHESIS AND RELEASE OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS [J].

BURKA, JF ;

FLOWER, RJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1979, 65 (01) :35-41

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