EVIDENCE FOR A PGE-RECEPTOR IN THE RAT-KIDNEY

被引：33

作者：

OIEN, HG

BABIARZ, EM

SODERMAN, DD

HAM, EA

KUEHL, FA

机构：

[1] Merck Institute for Therapeutic Research Rahway

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 04期

关键词：

D O I：

10.1016/0090-6980(79)90005-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A membrane preparation derived from homogenates of the rat kidney has been shown to possess a high affinity for prostaglandins of the E-series. Other prostaglandins including PGI2 had characteristic but significantly weaker binding properties. A 15-hydroxyprostaglandin dehydrogenase (PGDH) was found to be associated with the membrane fraction studied. However it was possible to distinguish between this and the receptor" binding by kinetic studies and by the use of a new inhibitor highly specific for PGDH. © 1979."

引用

页码：525 / 542

页数：18

共 16 条

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