THE CEPHALOGASTRIC PHASE OF THE PANCREATIC RESPONSE TO FOOD IN THE DOG

被引：8

作者：

JOHNSON, CD ^{[1
]}

DEVAUX, MA ^{[1
]}

TREFFOT, MJ ^{[1
]}

SARLES, H ^{[1
]}

机构：

[1] INSERM,U315,46 BD GAYE,F-13009 MARSEILLE,FRANCE

来源：

PANCREAS | 1991年 / 6卷 / 02期

关键词：

PANCREATIC SECRETION; TEST MEAL; VAGOTOMY; GASTRIN; VAGAL REFLEXES;

D O I：

10.1097/00006676-199103000-00010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We studied post-meal pancreatic secretion and gastrin release in conscious dogs with duodenal Thomas cannulas. Normal dogs were tested in physiological conditions and with an i.v. infusion of atropine 20-mu-g/kg/h or secretin 0.5 CU/kg/h. The responses were also studied after antral and truncal vagotomy. In the early phase (0-20 min) of the response, before gastric emptying started, antral vagotomy reduced fluid and protein outputs, and truncal vagotomy reduced them still more. Atropine reduced only the protein response. Gastrin release reached a peak after 20-25 min. After antral and truncal vagotomy, gastrin release was reduced within 10 min after the meal. Late-phase (> 20 min) pancreatic secretion depended on the presence of chyme in the duodenum. The effects of atropine and antral vagotomy in the cephalogastric phase could be explained by antropancreatic reflexes stimulating fluid secretion (atropine-resistant pathway) and protein output (atropine-sensitive pathway).

引用

页码：190 / 196

页数：7

共 24 条

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