CALCITONIN GENE-RELATED PEPTIDE AUGMENTS PARASYMPATHETIC CONTRACTION OF RABBIT TRACHEAL SMOOTH-MUSCLE INVITRO

被引：6

作者：

KANEMURA, T ^{[1
]}

TAMAOKI, J ^{[1
]}

HORII, S ^{[1
]}

SAKAI, N ^{[1
]}

KOBAYASHI, K ^{[1
]}

ISONO, K ^{[1
]}

TAKEUCHI, S ^{[1
]}

TAKIZAWA, T ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,DEPT MED 1,8-1 KAWADA CHO,SHINJU KU,TOKYO 162,JAPAN

来源：

AGENTS AND ACTIONS | 1990年 / 31卷 / 3-4期

关键词：

D O I：

10.1007/BF01997611

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of calcitonin gene-related peptide (CGRP) on parasympathetic contraction of rabbit airway smooth muscle was studied under isometric conditions in vitro. CGRP (10-7M) did not contract tracheal smooth muscle, but it potentiated the contractile response to electrical field stimulation (EFS) in a dose-dependent manner, the maximal increase from the baseline response being 14.4±6.2%. In contrast, the contractile responses to exogenously administered acetylcholine were not altered by this peptide. The CGRP-induced potentiation of the contractile responses to EFS was further augmented by physostigmine (123.1%), but not influenced by phentolamine, propranolol, indomethacin, or thiorphan, an enkephalinase inhibitor. These results suggest that CGRP augments the neurally mediated contraction of rabbit airway smooth muscle probably through a prejunctional mechanism and that this effect may not be modulated by tissue enkephalinase. © 1990 Birkhäuser Verlag.

引用

页码：219 / 224

页数：6

共 30 条

[1] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS [J].

AMARA, SG ;

JONAS, V ;

ROSENFELD, MG ;

ONG, ES ;

EVANS, RM .

NATURE, 1982, 298 (5871) :240-244

[2]

BARNES PJ, 1987, BR J PHARM, V90

[3]

BORSON DB, 1986, PHYSIOLOGIST, V29, P174

[4] CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR [J].

BRAIN, SD ;

WILLIAMS, TJ ;

TIPPINS, JR ;

MORRIS, HR ;

MACINTYRE, I .

NATURE, 1985, 313 (5997) :54-56

[5] OCCURRENCE, DISTRIBUTION AND ONTOGENY OF CGRP IMMUNOREACTIVITY IN THE RAT LOWER RESPIRATORY-TRACT - EFFECT OF CAPSAICIN TREATMENT AND SURGICAL DENERVATIONS [J].

CADIEUX, A ;

SPRINGALL, DR ;

MULDERRY, PK ;

RODRIGO, J ;

GHATEI, MA ;

TERENGHI, G ;

BLOOM, SR ;

POLAK, JM .

NEUROSCIENCE, 1986, 19 (02) :605-+

[6] LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN NEURONS OF THE RAT GASTROINTESTINAL-TRACT [J].

CLAGUE, JR ;

STERNINI, C ;

BRECHA, NC .

NEUROSCIENCE LETTERS, 1985, 56 (01) :63-68

[7] HUMAN CALCITONIN GENE-RELATED PEPTIDE ACTIVATES ADENYLATE-CYCLASE AND RELEASES PROSTACYCLIN FROM HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS [J].

CROSSMAN, D ;

MCEWAN, J ;

MACDERMOT, J ;

MACINTYRE, I ;

DOLLERY, CT .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 92 (04) :695-701

[8]

DUSSER DJ, 1988, J PHARMACOL EXP THER, V244, P531

[9] HUMAN-KIDNEY ENKEPHALINASE, A NEUTRAL METALLOENDOPEPTIDASE THAT CLEAVES ACTIVE PEPTIDES [J].

GAFFORD, JT ;

SKIDGEL, RA ;

ERDOS, EG ;

HERSH, LB .

BIOCHEMISTRY, 1983, 22 (13) :3265-3271

[10] CO-LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY WITH SUBSTANCE-P IN CUTANEOUS, VASCULAR AND VISCERAL SENSORY NEURONS OF GUINEA-PIGS [J].

GIBBINS, IL ;

FURNESS, JB ;

COSTA, M ;

MACINTYRE, I ;

HILLYARD, CJ ;

GIRGIS, S .

NEUROSCIENCE LETTERS, 1985, 57 (02) :125-130

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