THE ANALYSIS OF QUATERNARY AMMONIUM-COMPOUNDS IN HUMAN URINE BY DIRECT INLET ELECTRON-IMPACT IONIZATION MASS-SPECTROMETRY

被引：14

作者：

NISIKAWA, M ^{[1
]}

TATSUNO, M ^{[1
]}

SUZUKI, S ^{[1
]}

TSUCHIHASHI, H ^{[1
]}

机构：

[1] KINKI REG POLICE BUR,CTR IDENTIFICAT,CHUO KU,OSAKA 540,JAPAN

来源：

FORENSIC SCIENCE INTERNATIONAL | 1991年 / 51卷 / 01期

关键词：

QUATERNARY AMMONIUM COMPOUNDS; DIRECT INLET MASS SPECTROMETRY; MASS CHROMATOGRAPHY;

D O I：

10.1016/0379-0738(91)90213-3

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

An accurate and rapid screening test for nine quaternary ammonium compounds (suxamethonium chloride, pancuronium bromide, ambenonium chloride, benzethonium chloride, distigmine bromide, methylbenactyzium bromide, neostigmine bromide, propantheline bromide and pyridostigmine bromide) by direct inlet electron impact ionization mas spectrometry (DI/EI-MS) was investigated. Each compound was extracted from urine as an ion pair with KI3 into dichloromethane. The reliability of the identification of these compounds was verified by the mass chromatographic analysis of their characteristic fragment ions. The analysis of these drugs by DI/EI-MS could be performed within 5 min. The detection limits were between 20-150 ng/ml for the nine compounds. This method appears to be efficient, rapid and suitable as a screening procedure for the quaternary ammonium compounds found in urine.

引用

页码：131 / 138

页数：8

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