THE CENTRAL PRESSOR ACTIONS OF A NOVEL TACHYKININ PEPTIDE, GAMMA-PREPROTACHYKININ-(72-92)-PEPTIDE AMIDE

被引：5

作者：

HAGIO, T

TAKANO, Y

NAGASHIMA, A

NAKAYAMA, Y

TATEISHI, K

KAMIYA, H

机构：

[1] FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81401,JAPAN

[2] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM 1,FUKUOKA 81401,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 01期

关键词：

SUBSTANCE-P; NEUROPEPTIDE-GAMMA; CARDIOVASCULAR REGULATION; TACHYKININ PEPTIDES;

D O I：

10.1016/0014-2999(91)90086-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracerebroventricular (i.c.v.) injections of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide (neuropeptide-gamma, NP-gamma), caused dose-dependent increases in blood pressure. The NP-gamma-induced pressor responses (1-mu-g i.c.v.) were blocked by peripheral administration of pentolinium (10 mg/kg i.v.) and phentolamine (10 mg/kg i.v.), but were not inhibited by a vasopressin antagonist. These results suggest that central NP-gamma increases the blood pressure via sympathetic nerve activity.

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页码：173 / 176

页数：4

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