COLLAGEN TOXICITY IN RABBITS

被引：3

作者：

GOMES, SA

THOMSON, M

ALI, M

ALNAQEEB, M

KHATER, SH

机构：

[1] KUWAIT UNIV, DEPT BIOCHEM, POB 5969, SAFAT 13060, KUWAIT

[2] KUWAIT UNIV, FAC SCI, DEPT ZOOL, SAFAT 13060, KUWAIT

来源：

TOXICOLOGY LETTERS | 1991年 / 56卷 / 1-2期

关键词：

COLLAGEN; LACTATE DEHYDROGENASE; LIVER; LUNG; HISTOPATHOLOGY;

D O I：

10.1016/0378-4274(91)90110-R

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Different preparations of soluble collagen, from rabbit skin, rat tail tendon and guinea-pig skin produced respiratory distress, agitation, convulsion and finally death when infused intravenously in lethal doses. Analysis of plasma enzyme levels indicated significant increases in total, cardiac and hepatic lactate dehydrogenase, suggesting that damage to the liver occurred as a result of collagen infusion. Histopathological examination of lungs, livers and hearts of collagen-treated rabbits confirmed that damage had occurred to the lungs and livers of these animals, while heart tissues appeared to be normal. The source of collagen did not appear to influence its toxicity at the tissue level.

引用

页码：229 / 235

页数：7

共 17 条

[1] REVERSIBLE AND IRREVERSIBLE INHIBITION OF PLATELET CYCLOOXYGENASE AND SEROTONIN RELEASE BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].