CALCIUM-CHANNEL BLOCKERS AND EXCITATORY AMINO-ACIDS

被引:23
作者
KARLER, R
CALDER, LD
TURKANIS, SA
机构
[1] Department of Pharmacology, University of Utah School of Medicine, Salt Lake City
关键词
CALCIUM CHANNEL BLOCKER; EXCITATORY AMINO ACID; N-METHYL-D-ASPARTIC ACID; KAINIC ACID; ANTICONVULSANT; NEURODEGENERATIVE DISEASE; EPILEPSY;
D O I
10.1016/0006-8993(91)90952-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The calcium channel blockers (CCB), diltiazem, verapamil and nifedipine, antagonize in mice both N-methyl-DL-aspartate- (NMDLA) and kainate-induced convulsions, which were not affected by carbamazepine and ethosuximide. The CCB, on the other hand, were ineffective against convulsions induced by bicuculline, pentylenetetrazol and electroshock. The results suggest that the CCB may be efficatious in the treatment of those neurodegenerative diseases putatively caused by the excitatory amino acids.
引用
收藏
页码:331 / 333
页数:3
相关论文
共 13 条
[1]  
BINNIE CD, 1989, ANTIEPILEPTIC DRUGS, P971
[2]   GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].
CHOI, DW .
NEURON, 1988, 1 (08) :623-634
[3]  
HOFFMEISTER F, 1982, ARZNEIMITTEL-FORSCH, V32-1, P347
[4]  
JANIS RA, 1985, CARDIOVASCULAR EFFEC, P140
[5]   AMPHETAMINE BEHAVIORAL SENSITIZATION AND THE EXCITATORY AMINO-ACIDS [J].
KARLER, R ;
CHAUDHRY, IA ;
CALDER, LD ;
TURKANIS, SA .
BRAIN RESEARCH, 1990, 537 (1-2) :76-82
[6]   PROLONGED CNS HYPEREXCITABILITY IN MICE AFTER A SINGLE EXPOSURE TO DELTA-9-TETRAHYDROCANNABINOL [J].
KARLER, R ;
CALDER, LD ;
TURKANIS, SA .
NEUROPHARMACOLOGY, 1986, 25 (04) :441-446
[7]   REGULATION OF NEURONAL FUNCTION BY CALCIUM [J].
KENNEDY, MB .
TRENDS IN NEUROSCIENCES, 1989, 12 (11) :417-420
[8]  
MELDRUM B, 1987, EXCITATORY AMINO ACI, P189
[9]  
OLNEY JW, 1990, ANNU REV PHARMACOL, V30, P47
[10]  
Prince D A, 1986, Adv Neurol, V44, P275