DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ENHANCE ATP-ACTIVATED CURRENTS

被引：26

作者：

INOUE, K ^{[1
]}

NAKAZAWA, K ^{[1
]}

WATANO, T ^{[1
]}

OHARAIMAIZUMI, M ^{[1
]}

FUJIMORI, K ^{[1
]}

TAKANAKA, A ^{[1
]}

机构：

[1] NATL INST HYG SCI,DIV PHARMACOL,TOKYO 158,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

关键词：

ATP; ION CHANNELS; DOPAMINE; DOPAMINE RECEPTOR AGONISTS; DOPAMINE RECEPTOR ANTAGONISTS; PHEOCHROMOCYTOMA PC12 CELLS;

D O I：

10.1016/0014-2999(92)90049-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of dopamine and related compounds on ATP-activated channels were investigated in pheochromocytoma PC12 cells. Dopamine (10-mu-M) enhanced an inward current activated by 100-mu-M ATP. A similar enhancement of the ATP-activated current was observed with apomorphine (10-mu-M), a non-selective dopamine receptor agonist, with (+)-SKF-38393 (10-mu-M), a selective dopamine D1 receptor agonist, and with (-)-quinpirole (10-mu-M), a selective dopamine D2 receptor agonist. Moreover, (+)-SCH-23390 (30-mu-M), a dopamine D1 receptor antagonist, and (-)-sulpiride (30-mu-M), a dopamine D2 receptor antagonist, also enhanced the ATP-activated current. The results suggest that ATP-activated channels are modulated by dopaminergic mechanisms, and that this modulation cannot be attributed to any single class of dopamine receptors.

引用

页码：321 / 324

页数：4

共 10 条

[1] ACTIVATION OF FACILITATION CALCIUM CHANNELS IN CHROMAFFIN CELLS BY D1 DOPAMINE-RECEPTORS THROUGH A CAMP PROTEIN KINASE-A-DEPENDENT MECHANISM [J].