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THE MULTIPLE FUNCTIONS OF HEMOGLOBIN

被引：172
作者：
GIARDINA, B
MESSANA, I
SCATENA, R
CASTAGNOLA, M
机构：
[1] CNR, CTR STUDIO CHIM RECETTORI & MOLEC BIOLOGICAMENTE, ROME, ITALY
[2] UNIV CAGLIARI, IST CHIM BIOL, CAGLIARI, ITALY
来源：
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1995年 / 30卷 / 03期
关键词：
HEMOGLOBIN; FUNCTION;
D O I：
10.3109/10409239509085142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this review is to focus and discuss several parallel biological functions of hemoglobin besides its basic function of oxygen transport. In light of the information present in the literature the following possible physiological roles of hemoglobin are discussed: (1) hemoglobin as molecular heat transducer through its oxygenation-deoxygenation cycle, (2) hemoglobin as modulator of erythrocyte metabolism, (3) hemoglobin oxidation as an onset of erythrocyte senescence, (4) hemoglobin and its implication in genetic resistance to malaria, (5) enzymatic activities of hemoglobin and interactions with drugs, and (6) hemoglobin as source of physiological active catabolites.
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页码：165 / 196
页数：32
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