IMMUNOGENETIC, CLINICAL, AND DEMOGRAPHIC CHARACTERIZATION OF CHILDHOOD TYPE-I DIABETES IN NEW-ZEALAND

被引:5
作者
FORBES, LV [1 ]
SCOTT, RS [1 ]
BROWN, LJ [1 ]
DARLOW, BA [1 ]
机构
[1] CHRISTCHURCH HOSP,LIPID & DIABET RES GRP,CHRISTCHURCH,NEW ZEALAND
关键词
D O I
10.2337/diacare.18.11.1428
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To examine the relationship between genetic susceptibility alleles and islet cell antibodies (ICAs) in type I diabetes. RESEARCH DESIGN AND METHODS - The human leukocyte antigen (HLA)-DQB1 alleles and ICA levels of all incident type I diabetic cases in patients <20 years of age diagnosed in 1990 and 1991 in Canterbury, New Zealand, were determined. RESULTS - The mean annual incidence rate for type I diabetes over the 24 months was 19.0/100,000 patient-years (95% confidence interval [Cl] 13.5-26.0/100,000), which was considerably higher than rates observed between 1982 and 1989 (11.7/ 100,000; 95% CI 9.6-14.3/100,000). ICAs greater than or equal to 10 Juvenile Diabetes Foundation units (JDF U) were present in 84.6% of the subjects, but there was a higher prevalence of ICA-negative (ICA(-)) subjects among those diagnosed during the winter months. The frequencies of the susceptibility allele DQB1*0302 and susceptibility genotype 0302/ 0201 were 71.8% and 43.5%, respectively. Subjects with 0302 tended to be younger (mean age 8.3 +/- 5.1 years) than those with nonsusceptibility types (mean age 11.8 +/- 4.7 years, P = 0.056), The probability of being ICA positive (ICA(+)) was not significantly different between subjects with allele 0302 (85.7%) and those without it (81.8%). All seven patients negative for ICA were homozygous for DQB1 nonaspartate-57. There was no clustering of the immunogenetic markers with demographic and clinical characteristics apart from age at diagnosis. CONCLUSIONS - No direct relationship was observed between DQB1-defined genetic susceptibility and ICA at diagnosis, suggesting that variations at the DQB1 locus are not linked to the expression of this autoimmune marker of beta-cell destruction.
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页码:1428 / 1433
页数:6
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