THE HEMIDESMOSOME - A TARGET IN AUTOIMMUNE BULLOUS DISEASE

被引：17

作者：

EADY, RAJ ^{[1
]}

机构：

[1] UNIV LONDON,UNITED MED & DENT SCH,ST JOHNS INST DERMATOL,LONDON,ENGLAND

来源：

DERMATOLOGY | 1994年 / 189卷

关键词：

HEMIDESMOSOME; BASEMENT MEMBRANE; BULLOUS PEMPHIGOID ANTIGEN; ANCHORING FILAMENT; ALPHA-6-BETA-4-INTEGRIN;

D O I：

10.1159/000246926

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hemidesmosomes are subcellular structures that are involved in the attachment of a variety of epithelial cells, including basal epidermal keratinocytes, to the extracellular matrix. Like desmosomes, they provide a link between the intracytoplasmic keratin intermediate filaments and the plasma membrane. Major hemidesmosome plaque components include the bullous pemphigoid antigens of 230 and 180 kD and the alpha 6 beta 4-integrin. These transmembrane proteins may associate extracellularly with anchoring filament components including the 19-DEJ-1 proteoglycan and the polymeric proteins nicein/kalinin and epiligrin. Several of these hemidesmosome-related components have been implicated as targets for circulating auto-antibodies in immunobullous disorders.

引用

页码：38 / 41

页数：4

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