DOES THE HIV NEF PROTEIN MIMIC THE MHC

被引：7

作者：

HOBOHM, U

SANDER, C

机构：

[1] European Molecular Biology Laboratory

来源：

FEBS LETTERS | 1993年 / 333卷 / 03期

关键词：

HIV; NEF; MHC; PROTEIN MIMICRY;

D O I：

10.1016/0014-5793(93)80655-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of the HIV Nef protein has no significant homology to other proteins in the SwissProt database, and experimental data concerning its function are sparse and contradictory. Using a novel protein sequence comparison method, we find similarities between different Nef sequences and the alpha chain of human MHC class I proteins. The possible biological implications of this finding are discussed.

引用

页码：211 / 213

页数：3

共 17 条

[1] THE SWISS-PROT PROTEIN-SEQUENCE DATA-BANK
BAIROCH, A
BOECKMANN, B
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 : 2247 - 2248
[2] A COMPLEX BETWEEN THE MHC CLASS-I HOMOLOG ENCODED BY HUMAN CYTOMEGALOVIRUS AND BETA-2 MICROGLOBULIN
BROWNE, H
SMITH, G
BECK, S
MINSON, T
[J]. NATURE, 1990, 347 (6295) : 770 - 772
[3] AN ADENOVIRUS TYPE-2 GLYCOPROTEIN BLOCKS CELL-SURFACE EXPRESSION OF HUMAN HISTOCOMPATIBILITY CLASS-I ANTIGENS
BURGERT, HG
KVIST, S
[J]. CELL, 1985, 41 (03) : 987 - 997
[4] GOODING LR, 1992, CELL, V71, P5
[5] MUTATIONAL ANALYSIS OF THE HIV NEF PROTEIN
GUY, B
RIVIERE, Y
DOTT, K
REGNAULT, A
KIENY, MP
[J]. VIROLOGY, 1990, 176 (02) : 413 - 425
[6] HAASE A T, 1992, Current Biology, V2, P130, DOI 10.1016/0960-9822(92)90249-A
[7] NEF PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 - EVIDENCE AGAINST ITS ROLE AS A TRANSCRIPTIONAL INHIBITOR
HAMMES, SR
DIXON, EP
MALIM, MH
CULLEN, BR
GREENE, WC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) : 9549 - 9553
[8] HOBOHM U, UNPUB
[9] Holmes Ken C., 1993, Trends in Cell Biology, V3, P53, DOI 10.1016/0962-8924(93)90161-S
[10] IMPORTANCE OF THE NEF GENE FOR MAINTENANCE OF HIGH VIRUS LOADS AND FOR DEVELOPMENT OF AIDS
KESTLER, HW
RINGLER, DJ
MORI, K
PANICALI, DL
SEHGAL, PK
DANIEL, MD
DESROSIERS, RC
[J]. CELL, 1991, 65 (04) : 651 - 662

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