DISODIUM-CROMOGLYCATE - NOVEL GASTRIC ANTI-ULCER AGENT

被引：29

作者：

OGLE, CW

LAU, HK

机构：

[1] Department of Pharamcology, Faculty of Medicine, University of Hong Kong

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 55卷 / 04期

关键词：

Disodium cromoglycate; Gastric ulcer; reserpine;

D O I：

10.1016/0014-2999(79)90117-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of oral pretreatment with disodium cromoglycate (2.5 or 5 mg/kg × 9 doses) on the 4-h gatsric effects of i.p. injected reserpine (5 mg/kg) was examined in rats. Disodium cromoglycate markedly prevented reserpine-induced ulceration, mucosal mast cell degranulation and superficial mucosal microcirculatory changes in the glandular portion of the stomach wall. These interesting result point to the possibility that disodium cromoglycate may also have gatsric effects in man. © 1979.

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页码：411 / 415

页数：5

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