EFFECT OF ACTH AND CORTICOSTERONE ON MELANOGENESIS AND CYCLIC NUCLEOTIDE LEVELS IN THE B-16-MELANOMA

被引：3

作者：

ABRAMOWITZ, J ^{[1
]}

CHAVIN, W ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT BIOL,DETROIT,MI 48202

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1979年 / 264卷 / 03期

关键词：

Adrenocorticotropin; cAMP; cGMP; Corticosterone; Cyclic nucleotides; Melanogenesis; Melanoma;

D O I：

10.1007/BF00412656

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The acute in vitro action of ACTH and corticosterone individually and in combination were determined in the B-16 melanoma grown in vivo. ACTH elevated levels 10-fold while tyrosinase activity generally was depressed. Corticosterone depressed cAMP levels and tyrosinase activity. ACTH in the presence of corticosterone produced a coincident peak in tyrosinase activity and cAMP levels followed by a depression of enzymatic activity. The results demonstrate that cAMP is not the sole modulator of tyrosinase activity and that ACTH, corticosterone and cAMP interact in the regulation of B-16 melanoma tyrosinase activity. © 1979 Springer-Verlag.

引用

页码：293 / 298

页数：6

共 21 条

[1] INTERACTION OF ACTH, CORTICOSTERONE AND CYCLIC NUCLEOTIDES IN HARDING-PASSEY MELANOMA MELANOGENESIS [J].