CHROMOSOMAL INSERTION AND AMPLIFICATION OF HUMAN PAPILLOMAVIRUS 16-DNA SEQUENCES IN A CELL-LINE OF ARGYROPHIL SMALL-CELL CARCINOMA OF THE UTERINE CERVIX

被引：24

作者：

HORI, T

ICHIMURA, H

MINAMIHISAMATSU, M

TAKAHASHI, E

YAMAUCHI, M

HAMA, Y

KURIMURA, O

YAMASAKI, M

KURIMURA, T

机构：

[1] OSAKA UNIV,AGR EXPT STN RES INST,DEPT PATHOL,SUITA,OSAKA 565,JAPAN

[2] NATL INST RADIOL SCI,DIV RADIAT HAZARD,CHIBA 260,JAPAN

[3] KURE NATL HOSP,INST CLIN RES,KURE 737,JAPAN

[4] OSAKA ROSAI HOSP,DEPT OBSTET & GYNECOL,SAKAI 591,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1991年 / 82卷 / 04期

关键词：

CERVICAL CARCINOMA; HUMAN PAPILLOMAVIRUS (HVP-16); FLUORESCENCE INSITU; HYBRIDIZATION;

D O I：

10.1111/j.1349-7006.1991.tb01857.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chromosomal location of human papillomavirus (HPV) 16 DNA sequences integrated in a cell line derived from argyrophil small cell carcinoma of the uterine cervix was determined by means of fluorescence in situ hybridization (FISH). The HPV 16 DNA sequences were integrated near a fragile site and the location of the c-myc oncogene at 8q24.1. Amplification of the integrated viral sequences resulted in an abnormally banded region. The amplified HPV 16 DNA sequences were also detected in every interphase nucleus by FISH.

引用

收藏

页码：371 / 375

页数：5

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