SUBCHRONIC ORAL TOXICITY (6 MONTHS) OF CARBOXYETHYLGERMANIUM SESQUIOXIDE [(HOOCCH2CH2GE)2O3]N IN RATS

被引：13

作者：

ANGER, F ^{[1
]}

ANGER, JP ^{[1
]}

GUILLOU, L ^{[1
]}

PAPILLON, A ^{[1
]}

JANSON, C ^{[1
]}

SUBLET, Y ^{[1
]}

机构：

[1] LAB INTERREG FRAUDES, F-35000 RENNES, FRANCE

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1992年 / 6卷 / 03期

关键词：

CARBOXYETHYLGERMANIUM SESQUIOXIDE; SUBCHRONIC ORAL TOXICITY; RAT;

D O I：

10.1002/aoc.590060304

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

After briefly renewing toxicological data on germanium compounds, the authors report on the subchronic oral toxicity of carboxyethylgermanium sesquioxide in rats. During six months, male and female animals received 1 g kg-1 day-1. No particular toxic symptoms, and no behaviour problems except a small decrease of body weight in male rats, at the end of the six-month experimentation period, were observed. A significant decrease of erythropoiesis and some significant changes in leucocyte ratios were demonstrated. The main marked effect was a moderate renal dysfunction characterized by a tubular disease with the presence of cylinders, swelling of tubulous cells and flocculus deposits. Germanium urinary excretion was constant and linked to the received dose. Six months later, no preferential accumulation in organs was evident.

引用

页码：267 / 272

页数：6

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