PALLADIUM-CATALYZED ALLYLATION OF PYRIMIDINE-2,4-DIONES (URACILS) AND OF 6-MEMBERED HETEROCYCLIC AMBIDENT SULFUR NUCLEOPHILES

被引：39

作者：

MORENOMANAS, M

PLEIXATS, R

VILLARROYA, M

机构：

[1] Department of Chemistry. Universitat Autònoma de Barcelona., Bellaterra

来源：

TETRAHEDRON | 1993年 / 49卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(01)90197-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd(0)-Catalyzed allylation of six-membered ambident heterocycles bearing NH-CO, NH-CS and CH2-CO moieties obey the regioselectivity rules: C>O; N>O; S>N; NH-CO>NH-CS. Uracil and 5-methyluracil (thymine) do not show regioselectivity (N-1 = N-3) whereas 6-methyluracil is regioselectively allylated at N-3 (N-3>N-1).

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页码：1457 / 1464

页数：8

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