NOVEL CYTOTOXIC ANNONACEOUS ACETOGENINS - (2,4-CIS AND TRANS)-BULLADECINONES FROM ANNONA-BULLATA (ANNONACEAE)

被引：52

作者：

GU, ZM ^{[1
]}

FANG, XP ^{[1
]}

ZENG, L ^{[1
]}

KOZLOWSKI, JF ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80019-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A mixture of two novel cytotoxic adjacent bis-tetrahydrofuran (THF) ketolactone acetogenins, (2,4-cis and trans)-bulladecinones (1 and 2), was isolated from the bark of Annona bullara Rich, (Annonaceae). Adjacent bis-THF rings, located at C-12 and C-16 and having only one adjacent hydroxyl group, and the presence of an erythro vicinal diol in 1 and 2 are new features for the Annonaceous acetogenins.

引用

页码：473 / 478

页数：6

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