SELECTIVE INACTIVATION OF VIRUSES IN THE PRESENCE OF HUMAN PLATELETS - UV SENSITIZATION WITH PSORALEN DERIVATIVES

被引：30

作者：

GOODRICH, RP ^{[1
]}

YERRAM, NR ^{[1
]}

TAYGOODRICH, BH ^{[1
]}

FORSTER, P ^{[1
]}

PLATZ, MS ^{[1
]}

KASTURI, C ^{[1
]}

PARK, SC ^{[1
]}

AEBISCHER, JN ^{[1
]}

RAI, S ^{[1
]}

KULAGA, L ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT CHEM,COLUMBUS,OH 43210

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 12期

关键词：

BLOOD; VIRAL INACTIVATION;

D O I：

10.1073/pnas.91.12.5552

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inactivation of viruses in blood products requires that the method employed display selectivity in its action for viral elements while not affecting the biological entity of interest. Several methods have been developed for the treatment of human plasma of products derived from human plasma. An effective technique for the treatment of the cellular components of blood has been lacking, in part due to the inability to develop agents capable of selectively targeting viral agents in the milieu of cellular material. In this paper, we examine the behavior of a group of viral sensitizers designed to be added to cellular samples and be activated upon exposure to UVA light. Upon activation, these agents are capable of disrupting nucleic acids of the virus in a manner that renders them inactive for proliferation. The selectivity observed in this inactivation is determined by the chemical structure of the sensitizer, which can be varied to increase viral killing capacity while diminishing collateral damage to cellular and protein constituents.

引用

页码：5552 / 5556

页数：5

共 13 条

[1] THE EFFECTS OF OSMOTIC-STRESS ON HUMAN-PLATELETS [J].