STIMULATION OF SPINAL DELTA-OPIOID RECEPTORS IN MICE SELECTIVELY ENHANCES THE ATTENUATION OF DELTA-OPIOID RECEPTOR-MEDIATED ANTINOCICEPTION BY ANTISENSE OLIGODEOXYNUCLEOTIDE

被引：13

作者：

NARITA, M ^{[1
]}

TSENG, LF ^{[1
]}

机构：

[1] MED COLL WISCONSIN,DEPT ANESTHESIOL,MILWAUKEE,WI 53226

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 284卷 / 1-2期

关键词：

ANTISENSE OLIGODEOXYNUCLEOTIDE; DELTA-OPIOID RECEPTOR; DESENSITIZATION; ANTINOCICEPTION;

D O I：

10.1016/0014-2999(95)00414-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intrathecal (i.t.) pretreatment of male ICR mice with antisense oligodeoxynucleotide to delta-opioid receptor mRNA once a day for 1-3 days caused a time-dependent attenuation of i.t. administered [D-Ala(2)]deltorphin II-induced antinociception as measured by the tail-flick test. The attenuation of the antinociception induced by i.t. administered [D-Ala(2)]deltorphin II, a delta-opioid receptor agonist, was enhanced by i.t. pretreatment for 1 day with [D-Ala(2)]deltorphin II, but not [D-Ala(2),NMePhe(4),Gly(ol)(5)]enkephalin (DAMGO), a mu-opioid receptor agonist, or U50,488H, a kappa-opioid receptor agonist, given together with antisense oligodeoxynucleotide to delta-opioid receptor mRNA. The present results indicate that stimulation of spinal delta-opioid receptors by i.t. injection of [D-Ala(2)]deltorphin II selectively causes a loss of delta-opioid receptor-mediated antinociception in mice pretreated with antisense oligodeoxynucleotide to delta-opioid receptor mRNA.

引用

页码：185 / 189

页数：5

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