TEL1, A GENE INVOLVED IN CONTROLLING TELOMERE LENGTH IN SACCHAROMYCES-CEREVISIAE, IS HOMOLOGOUS TO THE HUMAN ATAXIA-TELANGIECTASIA GENE

被引：349

作者：

GREENWELL, PW

KRONMAL, SL

PORTER, SE

GASSENHUBER, J

OBERMAIER, B

PETES, TD

机构：

[1] UNIV N CAROLINA, CURRICULUM GENET & CELL BIOL, CHAPEL HILL, NC 27599 USA

[2] UNIV CHICAGO, DEPT MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA

[3] UNIV MUNICH, INST BIOCHEM, D-81375 MUNICH, GERMANY

来源：

CELL | 1995年 / 82卷 / 05期

关键词：

D O I：

10.1016/0092-8674(95)90479-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G(1-3)T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amio acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

引用

页码：823 / 829

页数：7

共 46 条

[1] DNA-REPAIR MUTANTS DEFINING G2 CHECKPOINT PATHWAYS IN SCHIZOSACCHAROMYCES-POMBE
ALKHODAIRY, F
CARR, AM
[J]. EMBO JOURNAL, 1992, 11 (04) : 1343 - 1350
[2] A SIMPLE AND EFFICIENT METHOD FOR DIRECT GENE DELETION IN SACCHAROMYCES-CEREVISIAE
BAUDIN, A
OZIERKALOGEROPOULOS, O
DENOUEL, A
LACROUTE, F
CULLIN, C
[J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (14) : 3329 - 3330
[3] BOEKE JD, 1987, METHOD ENZYMOL, V154, P164
[4] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX
BROWN, EJ
ALBERS, MW
SHIN, TB
ICHIKAWA, K
KEITH, CT
LANE, WS
SCHREIBER, SL
[J]. NATURE, 1994, 369 (6483) : 756 - 758
[5] AN ELECTROPHORETIC KARYOTYPE FOR YEAST
CARLE, GF
OLSON, MV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (11) : 3756 - 3760
[6] 2 DIFFERENTIALLY REGULATED MESSENGER-RNAS WITH DIFFERENT 5' ENDS ENCODE SECRETED AND INTRACELLULAR FORMS OF YEAST INVERTASE
CARLSON, M
BOTSTEIN, D
[J]. CELL, 1982, 28 (01) : 145 - 154
[7] TELOMERE SHORTENING ASSOCIATED WITH CHROMOSOME INSTABILITY IS ARRESTED IN IMMORTAL CELLS WHICH EXPRESS TELOMERASE ACTIVITY
COUNTER, CM
AVILION, AA
LEFEUVRE, CE
STEWART, NG
GREIDER, CW
HARLEY, CB
BACCHETTI, S
[J]. EMBO JOURNAL, 1992, 11 (05) : 1921 - 1929
[8] PHOSPHATIDYLINOSITOL 4-KINASE - GENE STRUCTURE AND REQUIREMENT FOR YEAST-CELL VIABILITY
FLANAGAN, CA
SCHNIEDERS, EA
EMERICK, AW
KUNISAWA, R
ADMON, A
THORNER, J
[J]. SCIENCE, 1993, 262 (5138) : 1444 - 1448
[9] FRIEDBERG EC, 1995, DNA REPAIR MUTAGENES, P662
[10] PIK1, AN ESSENTIAL PHOSPHATIDYLINOSITOL 4-KINASE ASSOCIATED WITH THE YEAST NUCLEUS
GARCIABUSTOS, JF
MARINI, F
STEVENSON, I
FREI, C
HALL, MN
[J]. EMBO JOURNAL, 1994, 13 (10) : 2352 - 2361

← 1 2 3 4 5 →