INTERACTIONS OF ANGIOTENSIN-II WITH CENTRAL CATECHOLAMINES

被引：21

作者：

JENKINS, TA

ALLEN, AM

CHAI, SY

MENDELSOHN, FAO

机构：

[1] Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 1995年 / 17卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

ANGIOTENSIN II; CATECHOLAMINE; NORADRENALINE; DOPAMINE; LOSARTAN; ACE INHIBITORS;

D O I：

10.3109/10641969509087070

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is a large body of anatomical and functional evidence supporting an interaction between brain angiotensin and central catecholamine systems. Angiotensin II AT1 receptors have been identified on dopamine containing cells in the substantia nigra and striatum of human brain using receptor autoradiography. Using in vivo microdialysis we have demonstrated that locally administered angiotensin II stimulates dopamine release from the striatum of conscious rats. Since some angiotensin receptor antagonists and angiotensin converting enzyme inhibitors can cross the blood brain barrier it is possible that they interact with the brain catecholaminergic systems.

引用

页码：267 / 280

页数：14

共 67 条

[1] LOCALIZATION AND CHARACTERIZATION OF ANGIOTENSIN-II RECEPTOR-BINDING AND ANGIOTENSIN CONVERTING ENZYME IN THE HUMAN MEDULLA-OBLONGATA [J].