LONGITUDINAL-STUDY OF HAND BONE DENSITOMETRY IN RHEUMATOID-ARTHRITIS

被引:72
作者
DEODHAR, AA
BRABYN, J
JONES, PW
DAVIS, MJ
WOOLF, AD
机构
[1] ROYAL CORNWALL HOSP,DUKE CORNWALL RHEUMATOL UNIT,TRURO TR1 2HZ,CORNWALL,ENGLAND
[2] KEELE UNIV,KEELE,STAFFS,ENGLAND
来源
ARTHRITIS AND RHEUMATISM | 1995年 / 38卷 / 09期
关键词
D O I
10.1002/art.1780380905
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To measure hand bone mineral content (BMC) by dual x-ray absorptiometry and to seek clinical correlates in patients with rheumatoid arthritis (RA), in a prospective, longitudinal study. Methods. Eighty-one patients with non-steroid-treated RA were assessed at baseline and at month 12, for hand BMC and for disease activity and severity. Hand BMC in patients was compared with that in a control group of 95 normal volunteers, and rate of loss was compared with that in 37 controls. Results. At the initial assessment, male and female patients with RA had lower hand BMC than controls, after correction for age, height, and weight (mean reduction 7.5% in men [P = 0.003] and 7.8% in women [P = 0.01]). After 1 year, there was a further loss of hand BMC in patients (median loss 3.25% in men [P = 0.001] and 1.46% in women [P = 0.05]), but normal controls did not have significant changes in their hand BMC. In patients with disease duration of <2 years at study entry, the parameters of disease activity improved over 1 year, but they lost significant amounts of hand BMC. Hand BMC loss correlated with baseline C-reactive protein levels. In those with RA of >2 years duration at entry, the Health Assessment Questionnaire scores and Larsen scores had worsened after 1 year, but there was no significant loss of hand BMC. Conclusion. Patients with RA had low hand BMC compared with normal controls, even within 2 years of disease onset. The rate of loss was highest in patients with early disease and correlated with measures of initial disease activity, This loss continued despite clinical improvement.
引用
收藏
页码:1204 / 1210
页数:7
相关论文
共 21 条
[1]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[2]  
BARWELL R, 1865, DISEASES JOINTS
[3]   BONE DENSITOMETRY MEASUREMENTS IN EARLY INFLAMMATORY DISEASE [J].
BHALLA, AK ;
SHENSTONE, B .
BAILLIERES CLINICAL RHEUMATOLOGY, 1992, 6 (02) :405-414
[4]   USE OF THE RADIOGRAPH TO MEASURE THE COURSE OF RHEUMATOID-ARTHRITIS - THE GOLD STANDARD VERSUS FOOLS GOLD [J].
BROWER, AC .
ARTHRITIS AND RHEUMATISM, 1990, 33 (03) :316-324
[5]   SPINAL TRABECULAR BONE-MINERAL CONTENT IN PATIENTS WITH NON-STEROID TREATED RHEUMATOID-ARTHRITIS [J].
COMPSTON, JE ;
CRAWLEY, EO ;
EVANS, C ;
OSULLIVAN, MM .
ANNALS OF THE RHEUMATIC DISEASES, 1988, 47 (08) :660-664
[6]   MEASUREMENT OF HAND BONE-MINERAL CONTENT BY DUAL-ENERGY X-RAY ABSORPTIOMETRY - DEVELOPMENT OF THE METHOD, AND ITS APPLICATION IN NORMAL VOLUNTEERS AND IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].
DEODHAR, AA ;
BRABYN, J ;
JONES, PW ;
DAVIS, MJ ;
WOOLF, AD .
ANNALS OF THE RHEUMATIC DISEASES, 1994, 53 (10) :685-690
[7]   EARLY RHEUMATOID DISEASE .1. ONSET [J].
FLEMING, A ;
CROWN, JM ;
CORBETT, M .
ANNALS OF THE RHEUMATIC DISEASES, 1976, 35 (04) :357-360
[8]   MEASUREMENT OF PATIENT OUTCOME IN ARTHRITIS [J].
FRIES, JF ;
SPITZ, P ;
KRAINES, RG ;
HOLMAN, HR .
ARTHRITIS AND RHEUMATISM, 1980, 23 (02) :137-145
[9]   GENERALIZED BONE LOSS IN PATIENTS WITH EARLY RHEUMATOID-ARTHRITIS [J].
GOUGH, AKS ;
LILLEY, J ;
EYRE, S ;
HOLDER, RL ;
EMERY, P .
LANCET, 1994, 344 (8914) :23-27
[10]   EFFECT OF HORMONE REPLACEMENT THERAPY ON BONE MASS IN RHEUMATOID-ARTHRITIS PATIENTS TREATED WITH AND WITHOUT STEROIDS [J].
HALL, GM ;
DANIELS, M ;
DOYLE, DV ;
SPECTOR, TD .
ARTHRITIS AND RHEUMATISM, 1994, 37 (10) :1499-1505