A GENERAL-METHOD FOR THE SYNTHESIS OF ISATINS - PREPARATION OF REGIOSPECIFICALLY FUNCTIONALIZED ISATINS FROM ANILINES

被引：62

作者：

HEWAWASAM, P

MEANWELL, NA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 40期

关键词：

D O I：

10.1016/0040-4039(94)85299-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method has been developed for regiospecific conversion of substituted anilines to isatins. The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with diethyl oxalate to furnish an alpha-ketoester. Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin.

引用

页码：7303 / 7306

页数：4

共 26 条

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