URIC-ACID IN PREGNANCY AND PREECLAMPSIA - AN ALTERNATIVE HYPOTHESIS

被引：10

作者：

FAY, RA ^{[1
]}

机构：

[1] NEPEAN HOSP,PENRITH,NSW 2750,AUSTRALIA

来源：

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | 1990年 / 30卷 / 02期

关键词：

D O I：

10.1111/j.1479-828X.1990.tb03246.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

EDITORIAL COMMENT: This hypothesis that the rise in serum uric acid in patients with preeclampsia is secondary to placental damage rather than alteration in renal function will interest readers. A major problem with the hypothesis is acceptance that raised serum uric acid levels are a feature of normal pregnancy although this was the finding in a careful study recently reported in this Journal (Carter J, Child A. Serum uric acid levels in normal pregnancy. Aust NZ J Obstet Gynaecol 1989; 29: 313–431). This hypothesis could be tested by performing uric acid clearance studies in normal pregnancy and in patients with preeclampsia and relating it to creatinine clearance. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：141 / 142

页数：2

共 16 条

[1] Carter J, Child A., Serum uric acid levels in normal pregnancy, Aust NZ J Obstet Gynaecol, 29, pp. 313-314, (1989)
[2] Redman CWG, Beilin LJ, Bonnar J., Renal function in pre‐eclampsia, Journal of Clinical Pathology, 29, pp. 91-94, (1976)
[3] Semple PF, Carswell W, Boyle JA., Serial studies of the renal clearance of urate and inulin during pregnancy and after the pueperum in normal women, Clin Sci Molec Med, 47, pp. 559-565, (1974)
[4] Dunlop W, Davidson JM., The effect of normal pregnancy on the renal handling of uric acid, Br J Obstet Gynaecol, 84, pp. 13-21, (1977)
[5] Fay RA, Bromham DR, Brooks JA, Gebski V., Platelets and uric acid in the prediction of pre‐eclampsia, Am J Obstet Gynecol, 152, pp. 1038-1039, (1985)
[6] Redman CWG, Beilin LJ, Bonnar J, Wilkinson RH., Plasma urate measurements in predicting fetal death in hypertensive pregnancy, Lancet, 1, pp. 1370-1373, (1976)
[7] Lang F., Renal handling of urate, Renal transport of organic substances, pp. 234-261, (1981)
[8] Fay RA, Hughes AO, Farron NT., Platelets in pregnancy: hyperdestruction in normal pregnancy, Obstet Gynecol, 61, pp. 238-240, (1983)
[9] Mckay DG., Chronic intravascular coagulation in normal pregnancy and pre‐eclampsia, Contrib Nephrol, 25, pp. 108-119, (1981)
[10] Howie PW, Purdie DW, Begg CB, Prentice CRM., The use of coagulation tests to predict the clinical progress of preeclampsia, Lancet, 3, pp. 323-325, (1976)

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