DISSOCIATIONS BETWEEN THE EFFECTS OF LSD ON BEHAVIOR AND RAPHE UNIT-ACTIVITY IN FREELY MOVING CATS

被引：36

作者：

TRULSON, ME

JACOBS, BL

机构：

来源：

SCIENCE | 1979年 / 205卷 / 4405期

关键词：

D O I：

10.1126/science.451617

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d-lysergic acid diethylamide (LSD) while studying the activity of raphe neurons in freely moving cats. Although the results provide general support for the hypothesis, there were several important dissociations. (i) Low doses of LSD produced only small decreases in raphe unit activity but significant behavioral changes; (ii) LSD-induced behavioral changes outlasted the depression of raphe unit activity; and (iii) raphe neurons were at least as responsive to LSD during tolerance as they were in the nontolerant condition. Copyright © 1979 AAAS.

引用

页码：515 / 518

页数：4

共 29 条

[1]

Aghajanian G., 1975, HDB PSYCHOPHARMACOLO, V6, P63

[2] LYSERGIC ACID DIETHYLAMIDE - SENSITIVE NEURONAL UNITS IN MIDBRAIN RAPHE [J].