CLONIDINE REDUCES SUBSTANCE-P BINDING IN RAT SPINAL-CORD MEMBRANE PREPARATION

被引：6

作者：

HAMA, AT ^{[1
]}

NAKATA, Y ^{[1
]}

SEGAWA, T ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,INST PHARMACEUT SCI,DEPT PHARMACOL,KASUMI 1-2-3,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 55卷 / 01期

关键词：

NEUROPHYSIOLOGICAL CHARACTERIZATION; NEURONS; PAIN;

D O I：

10.1254/jjp.55.157

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of clonidine on substance P (SP) binding was investigated using rat brain and spinal cord membrane preparations preincubated with various concentrations of clonide. [H-3]SP specific binding in the spinal cord was significantly decreased with 10(-4) M clonidine, but no effect on binding was seen in the brain. Scatchard analysis of SP binding indicated that B(max) was significanlty depressed without changing the affinity. The mechanism of clonidine-induced analgesia includes a spinal neural component and action on the SP receptors.

引用

页码：157 / 160

页数：4

共 14 条

[1]

CHARLTON CG, 1985, J NEUROSCI, V5, P1293

[2] SPINALLY ADMINISTERED EPINEPHRINE SUPPRESSES NOXIOUSLY EVOKED ACTIVITY OF WDR NEURONS IN THE DORSAL HORN OF THE SPINAL-CORD [J].